How long does it take to cure Kawasaki disease?

How long does it take for Kawasaki disease to be cured? Speaking of Kawasaki disease, everyone should be unfamiliar with it. In fact, another name for Kawasaki disease is mucocutaneous lymph node syndrome. Once the disease occurs, it will bring serious disasters to the patient and his family. In order to let everyone further understand how long it takes for Kawasaki disease to be cured, let's introduce it to you in detail below!

1. Acute Phase Treatment

Take the medicine within 10 days of onset.

Early oral aspirin can control the acute inflammatory process, and intravenous immunoglobulin plus oral aspirin treatment can reduce the incidence of coronary artery aneurysms in Kawasaki disease.

1. Intravenous infusion of immunoglobulin G 400 mg/kg per day, infused over 2 to 4 hours, for 4 consecutive days; at the same time, oral aspirin 50 to 100 mg/kg per day, divided into 3 to 4 times, for 4 consecutive days, and then reduced to 5 mg/kg per day, taken all at once.

2. The dosage of aspirin is 30-100 mg/kg per day, divided into 3-4 times. After taking it for 14 days, reduce it to 3-5 mg/kg per day, taken once, after the fever subsides, to achieve the anti-platelet aggregation effect.

3. Corticosteroids can be used in combination with prednisone and aspirin. In order to control the early inflammatory response of Kawasaki disease, corticosteroids are generally not used alone. Prednisone, oral, adults start with 15mg ~ 40mg / day, when necessary, can be increased to 60mg / day, take in divided doses, and gradually reduce the dose after the condition stabilizes. The maintenance dose is 5mg ~ 10mg / day.

2. Treatment during the recovery period

1. Anticoagulant therapy

Take aspirin 3-5 mg/kg per day, once a day, until the erythrocyte sedimentation rate and platelets return to normal. If there is no coronary artery abnormality, the drug is generally stopped 6-8 weeks after the onset of the disease. For patients with chronic residual coronary artery disease, long-term anticoagulant drugs and close follow-up are required. Patients with small single coronary artery aneurysms should take aspirin 3-5 mg/kg per day for a long time until the aneurysm disappears. For those who are intolerant to aspirin, 3-6 mg/kg per day can be used, divided into 2-3 doses. Patients with giant tumors are prone to thrombosis, coronary artery stenosis or occlusion, and oral warfarin anticoagulants can be used.

2. Thrombolytic therapy

Patients with myocardial infarction and thrombosis are given drugs intravenously or by percutaneous catheter puncture into the coronary artery to promote coronary recanalization and myocardial reperfusion. Urokinase 20,000u/kg is injected within 1 hour of intravenous thrombolysis, followed by 3,000-4,000u/kg per hour. Urokinase 1,000u/kg is injected within 1 hour of coronary artery administration. Streptokinase can also be used. Streptokinase 10,000u/kg is injected within 1 hour of intravenous thrombolysis, and it can be used again half an hour later. The above drugs quickly dissolve fibrin, with good effects and no adverse reactions.

3. Coronary angioplasty

In recent years, the use of balloon catheters to dilate coronary artery stenosis has been successful.

4. Surgical treatment

Indications for coronary artery bypass grafting are:

① The left main trunk is highly occluded;

②Multiple branches are highly occluded;

③ Near-high degree of occlusion of the left anterior descending branch. For severe mitral regurgitation, medical treatment is ineffective, and valvuloplasty or valve replacement can be performed.

5. If cardiogenic shock, heart failure and arrhythmia occur, appropriate treatment should be given.