Can Kawasaki disease be cured?

Many children often suffer from some diseases due to their weak immunity. If they are not discovered in time, it will have a greater impact on our patients' bodies. For example, can Kawasaki disease be cured? Let's learn about the treatment methods below. I hope it will be helpful to everyone.

Kawasaki disease is treated according to other symptoms of the heart, respiratory tract, digestive tract, and urinary system, such as cough, sputum, elevated myocardial enzymes, elevated transaminases, etc., such as myocardial nutrition and liver protection. In the early stages of Kawasaki disease, a large dose of aspirin is needed to combat the inflammatory response of Kawasaki disease. The recommended dose in China and Japan is a medium dose, that is, 30-50 mg of aspirin per kilogram of body weight per day, divided into 3 to 4 oral doses.

48 hours after the body temperature returns to normal, switch to a low-dose aspirin of 3-5 mg per kilogram of body weight per day, taken all at once, in order to counteract the procoagulant effect of platelets and prevent thrombosis in the coronary artery.

According to the time characteristics of the occurrence and disappearance of vasculitis caused by Kawasaki disease, low-dose aspirin is generally taken for at least 3 months, and whether to continue taking it will be determined based on the condition of the coronary arteries. If echocardiography does not find abnormalities in the coronary arteries, aspirin can be discontinued after 3-6 months. If coronary artery dilatation or coronary artery aneurysm formation occurs, low-dose aspirin needs to be continued until the coronary arteries return to normal.

Children with permanent coronary artery disease need to take aspirin for a long time depending on the severity of the coronary artery disease. For patients with coronary artery aneurysm diameter ≥ 6mm and combined with coronary artery stenosis or thrombosis, in addition to aspirin, other antithrombotic drugs such as warfarin and clopidogrel may also be needed for treatment.

Patients with myocardial infarction and thrombosis are given drugs intravenously or by percutaneous catheter puncture into the coronary artery to promote coronary recanalization and myocardial reperfusion. Urokinase 20,000u/kg is injected within 1 hour of intravenous thrombolysis, followed by 3,000-4,000u/kg per hour. Urokinase 1,000u/kg is injected within 1 hour of coronary artery administration. Streptokinase can also be used. Streptokinase 10,000u/kg is injected within 1 hour of intravenous thrombolysis, and it can be used again half an hour later. The above drugs quickly dissolve fibrin, with good effects and no adverse reactions.