How to detect polio?

Polio is an acute infectious disease caused by a virus that can seriously endanger physical health. Most patients are children between 1 and 6 years old. Children at this age cannot express themselves, so many parents ignore the symptoms of their children, which leads to the discovery of the disease. So what are the methods for detecting polio? The following is a detailed introduction, hoping it will be helpful to everyone.

1. Cerebrospinal fluid: Most of them are abnormal before paralysis. The appearance is slightly turbid, the pressure is slightly increased, the number of cells is slightly increased (25-500/mm3), neutrophils are more in the early stage, and mononuclear cells are mainly in the later stage. After the fever subsides, it quickly returns to normal. Sugar may increase slightly, chloride is mostly normal, protein increases slightly, and lasts for a long time. In a few patients, the cerebrospinal fluid can always be normal.

2. Peripheral blood picture: Most white blood cells are normal, but may increase in the early stage and secondary infection, mainly neutrophils, and the erythrocyte sedimentation rate increases in the acute stage

3. Virus isolation or antigen detection: Within 1 week of onset, the virus can be isolated from the nasopharynx and feces. The feces can remain positive for 2 to 3 weeks. Early isolation of the virus from the blood or cerebrospinal fluid is more significant. Tissue culture isolation is generally used. In recent years, PCR has been used to detect enterovirus RNA, which is faster and more sensitive than tissue culture.

4. Serological examination: The titer of type-specific immune antibodies can reach a peak at the end of the first week, especially the specific IgM rises faster than IgG. Neutralization test, complement fixation test and enzyme labeling can be used to detect specific antibodies. Among them, neutralization test is more commonly used because it has a longer positive period. The titer of double serum increases by 4 times or more can be diagnosed. The complement fixation test turns negative quickly. If the result is negative as expected and the neutralization test is positive, it often indicates a previous infection. If both are positive, it indicates a recent infection. Recently, the use of immunofluorescence technology to detect antigens and specific IgM monoclonal antibody enzyme labeling method is helpful for early diagnosis.

This is the end of the introduction to the methods of detecting polio. I believe everyone has a correct understanding of the disease. When children are young, they can be vaccinated to prevent the disease. There are two main types of polio vaccines, which can be selected according to family conditions. Once the child shows symptoms of the disease, go to the hospital for examination and treatment immediately.