What is the best way to treat Kawasaki disease?

There are not many patients with Kawasaki disease around us, so many people don’t know about it. In fact, Kawasaki disease is a very harmful pediatric disease, especially the specific cause of the disease. Up to now, the medical community has not given a clear indication. Therefore, patients with this disease should receive timely treatment. So what is the best way to treat Kawasaki disease? Let me briefly introduce it to you below.

1. Recent studies on immunoglobulin have confirmed that early intravenous infusion of immunoglobulin plus oral aspirin can reduce the incidence of Kawasaki disease coronary artery aneurysm. It must be emphasized that medication should be used within 10 days after onset. The dosage is daily intravenous infusion of immunoglobulin 400 mg/kg, infused over 2 to 4 hours, for 4 consecutive days; at the same time, oral aspirin 50 to 100 mg/kg·d, divided into 3 to 4 times, for 4 consecutive days, and then increased to 5 mg/kg·d, taken all at once.

2. Aspirin. Early oral aspirin can control the acute inflammatory process and reduce coronary artery lesions, but no controlled studies have shown that aspirin treatment can reduce the incidence of coronary artery aneurysms. The dosage is 30-100 mg kg per day, divided into 3-4 times. Japanese doctors tend to use small doses, based on the fact that they take large doses in the acute phase of Kawasaki disease. They believe that acute patients have reduced aspirin absorption and increased clearance, and that large doses are needed to achieve anti-inflammatory effects. After taking it for 14 days, reduce it to 3-5 mg/kg per day after the fever subsides, and take it once, which has a full anti-platelet aggregation effect.

3. Corticosteroids: It has always been believed that adrenal cortex hormones have strong anti-inflammatory effects and can relieve symptoms. However, it was later found that corticosteroids are prone to thrombosis, hinder the repair of coronary artery lesions, and promote aneurysm formation. Therefore, it is not appropriate to use corticosteroids such as prednisone alone for treatment. Unless there is a complication of severe myocarditis or persistent high fever in severe cases, prednisone and aspirin can be used in combination for treatment. In order to control the early inflammatory response of Kawasaki disease, corticosteroids are generally not used alone.

4. Anticoagulant therapy: For patients in the recovery stage, take aspirin 3-5 mg/kg per day, once a day, until the erythrocyte sedimentation rate and platelet count return to normal. If there is no coronary artery abnormality, the drug is generally stopped 6-8 weeks after onset. Repeat echocardiograms 6 months and 1 year thereafter. For patients with residual chronic coronary artery disease, long-term anticoagulant drugs and close follow-up are required.

The treatment method is different depending on the disease. The same is true for Kawasaki disease. We have already introduced some treatment measures for this disease very clearly above. Therefore, learn more about the disease. Once the disease is found, seek medical treatment in time and don't delay the disease!