What medicine should I take for Kawasaki disease?

What medicine should be taken for Kawasaki disease? Taking medicine when you are sick seems to have become a necessary process for treating diseases. Kawasaki disease is very common among children. After the onset of the disease, there will be a lot of symptoms, and it will bring more harm to the children. The medication for Kawasaki disease has also attracted the attention of many parents and friends. So, what medicine should be taken for Kawasaki disease?

1. Aspirin: Early oral aspirin can control the acute inflammatory process and reduce coronary artery lesions, but no controlled studies have shown that aspirin treatment can reduce the incidence of coronary artery aneurysms. The dosage is 30-100 mg kg per day, divided into 3-4 times. Japanese doctors tend to use small doses, based on the fact that those who take large doses during the acute phase of Kawasaki disease believe that acute patients have reduced aspirin absorption and increased clearance, and only large doses can achieve anti-inflammatory effects. Take it for 14 days, and after the fever subsides, reduce it to 3-5 mg/kg per day, taken once, to play an anti-platelet aggregation role.

2. Corticosteroids: It has always been believed that adrenal cortex hormones have a strong anti-inflammatory effect and can relieve symptoms, but it was later found that corticosteroids are prone to thrombosis, hinder the repair of coronary artery lesions, and promote aneurysm formation. Therefore, it is not appropriate to use corticosteroids such as prednisone alone for treatment. Unless there is a complication of severe myocarditis or a persistent high fever in severe cases, prednisone and aspirin can be used in combination for treatment. In order to control the early inflammatory response of Kawasaki disease, corticosteroids are generally not used alone.

3. Immunoglobulin: Studies have confirmed that early intravenous infusion of immunoglobulin plus oral aspirin can reduce the incidence of Kawasaki disease coronary artery aneurysms. It must be emphasized that the medication should be used within 10 days after the onset of the disease. The dosage is daily intravenous infusion of immunoglobulin 400mg/kg, infused over 2 to 4 hours, for 4 consecutive days; at the same time, oral aspirin 50-100mg/kg·d, divided into 3 to 4 times, for 4 consecutive days, and then increased to 5mg/kg·d, taken all at once.

The biggest harm of Kawasaki disease is damage to the coronary arteries. It is the main cause of coronary artery disease in children and a potential risk factor for coronary heart disease in adults. Therefore, once the symptoms of the disease are found, it is necessary to actively treat it and take good care of the child during the treatment so that he can recover health as soon as possible.