What medicine is good for patent ductus arteriosus

What medicine is good for patent ductus arteriosus? Patent ductus arteriosus is a common congenital heart disease in children. Parents are very anxious when their children suffer from this disease. If effective treatment is not carried out in time, it will cast a shadow on the child's future. Therefore, early detection and early treatment are very important for this disease. So, what medicine is good for patent ductus arteriosus?

Drug treatment for patent ductus arteriosus is mainly used to treat complications such as respiratory tract infection, heart failure, and endocarditis. If the baby has shortness of breath or heart failure after birth, the patient can first control the amount of fluid, assist breathing, and receive diuretics (furosemide 1 mg/kg intravenous injection) and cardiotonic (cedilanid 0.01-0.015 mg/kg intravenous injection) to improve cardiopulmonary function, and blood transfusion to correct anemia. Usually, the probability of premature infants suffering from patent ductus arteriosus is very high. Therefore, for premature infants with low weight (less than 1500g), the increase in blood oxygen content can promote the contraction and closure of the large ductus arteriosus, reducing or eliminating the shunt from the autonomic artery to the pulmonary artery. Respiratory tract infection requires antibiotic therapy. Endocarditis is treated with large doses of drug-sensitive antibiotics. If it cannot be controlled, surgery should be performed instead.

Treatment of patent ductus arteriosus in premature infants

(1) If the ductus arteriosus does not close at 24 s after indomethacin treatment and the symptoms do not improve, or if hypoxemia and hypercapnia persist despite adequate ventilation and oxygen support, and PC02>7.98 kPa (60 mmHg), simple ductus ligation should be performed urgently.

(2) Indomethacin treatment: Patients who have not responded to anti-heart failure treatment should be given indomethacin by nasogastric feeding. One dose every 8 hours, for a total of 3 times. Before medication, the white blood cell count should be within the normal range, platelets should be no less than 60×109/l (60,000/mm3), urea nitrogen <20mg, and bilirubin <12mg. During medication, urine volume, heart rate, appetite, and jaundice should be observed. After medication, urea nitrogen, electrolytes, echocardiography, and chest X-ray should be rechecked. Adverse reactions of indomethacin include renal failure, hyponatremia, worsening jaundice, bone marrow suppression causing thrombocytopenia, and coagulation disorders.