What medicine is good for treating patent ductus arteriosus?

What medicine is good for treating patent ductus arteriosus? In life, every part of our body may suffer from diseases, and diseases are also the most worrying thing. When a child suffers from patent ductus arteriosus, parents will be at a loss and don’t know how to deal with it. At this time, they have to go to the hospital for treatment. So, what medicine is good for treating patent ductus arteriosus?

The patent ductus arteriosus of the child is relatively large. Due to the large blood flow, the blood volume in the lungs increases. Children under 1 year old often suffer from complications such as pneumonia and heart failure. Parents should take their children to the hospital for treatment in time and actively use antibiotics, cardiotonic diuretics, oxygen inhalation and other treatment measures.

Medical history records that since the 1970s, in addition to the above-mentioned traditional medical treatments, some people have begun to try drug-induced closure of the ductus arteriosus for premature infants with patent ductus arteriosus. That is, the non-steroidal anti-inflammatory drug indomethacin is used to inhibit cyclooxygenase and prevent the synthesis of prostaglandins to offset its effect of dilating the ductus arteriosus and promote the contraction and closure of the ductus arteriosus. According to many clinical data at the time, although the ductus arteriosus may be reopened, usually more than 70% of the ductus arteriosus can be closed in the end, which is also a very optimistic effect. At present, there is still a disagreement on the timing, dosage and course of treatment of medication. But in general, it is not necessary to give indomethacin preventively on the day of birth of premature infants, but to start taking the medicine when clinical manifestations of large hemodynamic shunts appear. Generally, the first dose is 0.2 mg/kg, which can be intravenously or orally administered, and administered once every 24 hours for a total of three times. The dose can also be reduced to 0.1 mg/kg per day for 7 days to reduce the side effects of indomethacin. The best effect is given within three days after birth. A single dose of the drug may close the duct, but it may reopen, requiring further dosing.

If the duration exceeds 8 days, the dose needs to be increased to 0.25-0.3 mg/kg, and the efficacy is also poor. The overall efficacy is above 70%. If indomethacin is ineffective, ligation surgery is required. However, it should be pointed out that the side effects of indomethacin include renal insufficiency, hyponatremia, platelet insufficiency, gastrointestinal bleeding, impaired left ventricular diastolic function and pulmonary edema, so it must be used with caution.