What to do if you are deficient in trehalase? How to check for trehalase deficiency?

The digestive function of the human body is completed by mechanical digestion of gastrointestinal motility and chemical digestion of digestive enzymes. Digestive juice contains a large amount of digestive enzymes, which can promote the hydrolysis of sugar, fat and protein in food. From macromolecules to small molecules, so that they can be absorbed and utilized by the human body. Glucose, glycerol, glycerol-esters, amino acids, etc. are all soluble small molecules that can be absorbed by the small intestine. In clinical practice, insufficient digestive enzymes can cause a wide range of indigestion syndromes, such as flatulence, stomach fullness, nausea, abdominal pain, diarrhea, anorexia and other symptoms, and also affect the digestion and absorption of nutrients, causing hypoproteinemia, fatty diarrhea, fat-soluble vitamin deficiency, endocrine disorders, etc. The main causes of digestive enzyme deficiency are common in: chronic pancreatitis, cholelithiasis, cirrhosis, liver dysfunction, pancreatic cancer, chronic gastrointestinal diseases, pancreatic resection, gastric and bile resection, radiotherapy or chemotherapy side effects, senile digestive dysfunction, and long-term drinking. The mechanism of indigestion symptoms is very complex, and insufficient secretion or decreased function of digestive enzymes is an important link in the generation of indigestion symptoms.

The most common disaccharidase deficiency in adults is lactase deficiency. Lactase activity is highest in newborns and can be reduced to 10% of its maximum amount later. Adults with lactase deficiency are at this level. After infants are weaned, lactase gradually decreases, and diarrhea is easily caused when they take milk again. The deficiency of this enzyme is related to genetics, accounting for 5% to 30% in Caucasians and 75% in people of color, including Asians and Africans. Sucrose-isomaltase deficiency can be reduced to 10% to 20% of normal, and the intestinal mucosa is normal. The reason is still unknown. In addition, during gastrointestinal infections, disaccharidase can also be temporarily under-secreted.