How to detect early Kawasaki disease

How to detect early Kawasaki disease? When it comes to Kawasaki disease, everyone may not be very familiar with it. This disease is a vascular disease that occurs in children. If we find this disease, we must take the child to the hospital for a detailed examination in time. So, after arriving at the hospital, what examinations should we give the child? Let's take a look at the examination methods for Kawasaki disease.

1. Routine blood examination: In the acute and subacute phases, the white blood cell (WBC) count increases, being mainly neutrophils with a left-shifted nucleus; the platelet (PLT) count increases significantly, and the hemoglobin (Hb) decreases, indicating mild anemia.

2. Urinalysis: Proteinuria, red blood cells (RBC), and white blood cells (WBC) may be present, but the symptoms are mild.

3. Erythrocyte sedimentation rate (ESR) measurement: Most cases show a significant increase, with an average of about 70 mm per hour and a maximum of 180 mm.

4. Serum immunological test: In the acute phase, immunoglobulins M, G (IgM, IgG) and immune complexes (CIC) can all be elevated, with 50% to 70% of patients being detected one week after the onset of the disease and reaching a peak at 3 to 4 weeks; the absolute count of T suppressor cells (TS) is significantly reduced, the number of activated T helper cells (TH) is increased, and the TH/TS value is increased.

5. Determination of TXB2, the metabolite of thromboxane A2 (TXA2): it may increase.

Kawasaki disease treatment:

In most cases, this disease is a self-limiting disease. During the acute fever period, aspirin 80-150 mg/kg can be taken orally in 4 divided doses; the dose can be adjusted according to the blood drug concentration of 20-25 mg/dl. After the fever period, the dose can be reduced by 5-10 mg/kg, once a day; aspirin can slow the occurrence of coronary artery aneurysms and prevent thrombosis. During treatment, electrocardiograms and two-dimensional echocardiography tracking should be performed frequently, and coronary angiography can be performed if necessary. The course of aspirin treatment depends on the clinical course of the disease and is generally suitable for several months; if a coronary artery aneurysm occurs, treatment should continue until the coronary artery aneurysm subsides.

Patients at high risk of developing coronary artery aneurysms can be given 40 mg/kg of gamma globulin daily for 5 consecutive days while taking aspirin. Compared with aspirin alone, gamma globulin can significantly reduce coronary artery lesions.

The use of glucocorticoids is still controversial. Some people believe that it can promote the formation of aneurysms, but there are also reports that the use of impact doses of glucocorticoids in the early stages of the disease can prevent the occurrence of coronary artery aneurysms.

A small number of patients with large coronary artery aneurysms that cannot shrink require coronary artery bypass surgery.

After the detailed introduction in the above article, we all know how to check for Kawasaki disease. We all know the seriousness of this disease, so we must do the examination very seriously. As long as we do the examination seriously, I believe the patient will slowly recover. As long as we do the examination, we can treat the child.