Causes of Hirschsprung's disease

The causes of Hirschsprung's disease mainly include genetic factors and abnormal embryonic development. This disease is generally associated with gene mutations, especially mutations in specific genes that control intestinal nerve cells, such as the RET gene. In addition to genetic factors, Hirschsprung's disease is also related to the incomplete development of the large intestine nervous system during the embryonic period, which is manifested as the absence or abnormal development of intestinal ganglion cells. This condition may cause intestinal obstruction or other digestive system symptoms in newborns.

From a genetic perspective, if parents carry related gene mutations, their children may increase their risk of disease, but this does not mean that every pair of carrier parents will pass it on to their offspring. Environmental factors, such as exposure to certain drugs during pregnancy and the mother's poor health, may also have an adverse effect on embryonic development, leading to abnormal development of the congenital nervous system. In terms of physiological and pathological factors, the hindered development of intestinal ganglion cells during the embryonic period may be related to changes in the mother's immune status and malnutrition during pregnancy. However, the clear environmental triggers are still unclear, and research is still ongoing to further identify and explain the complex etiology.

From a genetic perspective, if parents carry related gene mutations, their children may increase their risk of disease, but this does not mean that every pair of carrier parents will pass it on to their offspring. Environmental factors, such as exposure to certain drugs during pregnancy and the mother's poor health, may also have an adverse effect on embryonic development, leading to abnormal development of the congenital nervous system. In terms of physiological and pathological factors, the hindered development of intestinal ganglion cells during the embryonic period may be related to changes in the mother's immune status and malnutrition during pregnancy. However, the clear environmental triggers are still unclear, and research is still ongoing to further identify and explain the complex etiology.

For families with a family history of dysplasia, genetic counseling and related gene screening are recommended to ensure comprehensive health management during pregnancy. Pregnant mothers should undergo regular prenatal checkups, maintain a healthy diet and lifestyle, and avoid exposure to harmful substances that may affect fetal development. If a newborn is suspected of having related symptoms, he or she should seek medical attention as soon as possible for necessary diagnosis and treatment. With the guidance of professional doctors and the help of modern medical technology, the symptoms of this disease can be effectively managed and improved in the early stages.